Assay Detail
Binding
CHEMBL4193872
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant full length N-terminal His-tagged human PI3K p110alpha/p85alpha expressed in baculovirus expression system using PIP2/PS as substrate after 1 hr by ADP-Glo luminescence assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of a Novel Series of 7-Azaindole Scaffold Derivatives as PI3K Inhibitors with Potent Activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 8.52 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217725 | — | — | 1 | 9.00 |
| CHEMBL4212775 | — | — | 1 | 9.00 |
| CHEMBL4213317 | — | — | 1 | 9.00 |
| CHEMBL4208385 | — | — | 1 | 9.00 |
| CHEMBL4204586 | — | — | 1 | 8.70 |
| CHEMBL4216255 | — | — | 1 | 8.70 |
| CHEMBL4214320 | — | — | 1 | 7.46 |
| CHEMBL4204119 | — | — | 1 | 7.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217725 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4212775 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4213317 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4208385 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4204586 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4216255 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4214320 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4204119 | — | IC50 | = | 51.0 | nM | 7.29 |