Assay Detail
Binding
CHEMBL4194320
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Modulation of recombinant human GluN1/GluN2B NMDA receptor expressed in mammalian cells assessed as inhibition of glutamate/glycine-induced intracellular calcium flux pretreated for 5 mins followed by glutamate/glycine addition measured after 5 mins by calcium 5 dye based FLIPR assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Glutamate NMDA receptor; GRIN1/GRIN2B (CHEMBL1907603) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Modulating GluN2B for the Treatment of Neurological and Psychiatric Disorders.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.88 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205952 | — | — | 1 | 8.70 |
| CHEMBL4211247 | — | — | 1 | 8.20 |
| CHEMBL4217661 | — | — | 1 | 8.00 |
| CHEMBL4206361 | — | — | 1 | 7.90 |
| CHEMBL4214203 | — | — | 1 | 7.80 |
| CHEMBL4202517 | — | — | 1 | 7.70 |
| CHEMBL4210730 | — | — | 1 | 7.70 |
| CHEMBL4206877 | — | — | 1 | 7.60 |
| CHEMBL4215686 | — | — | 1 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205952 | — | IC50 | = | 1.995 | nM | 8.70 |
| CHEMBL4211247 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL4217661 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4206361 | — | IC50 | = | 12.59 | nM | 7.90 |
| CHEMBL4214203 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL4202517 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4210730 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL4206877 | — | IC50 | = | 25.12 | nM | 7.60 |
| CHEMBL4215686 | — | IC50 | = | 50.12 | nM | 7.30 |