Assay Detail
Binding
CHEMBL4194660
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3gamma2 expressed in HEK293 cell membranes after 90 mins by liquid scintillation counting analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2 (CHEMBL4296054) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.34 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213357 | — | — | 1 | 6.03 |
| CHEMBL4216298 | — | — | 1 | 5.47 |
| CHEMBL4204097 | — | — | 1 | 5.26 |
| CHEMBL4208437 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213357 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4216298 | — | IC50 | = | 3390.0 | nM | 5.47 |
| CHEMBL4204097 | — | IC50 | = | 5510.0 | nM | 5.26 |
| CHEMBL4208437 | — | IC50 | = | 25000.0 | nM | 4.60 |