Assay Detail
Binding
CHEMBL4194716
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]EBOB from rat GABA-A receptor alpha6beta3delta expressed in HEK293 cell membranes after 90 mins in presence of GABA by liquid scintillation counting analysis
6
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Target
Gamma-aminobutyric acid receptor subunit alpha-6/beta-3/delta (CHEMBL4296053) ↗| Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
Publication
Structure-Function Evaluation of Imidazopyridine Derivatives Selective for δ-Subunit-Containing γ-Aminobutyric Acid Type A (GABAA) Receptors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Imax | 3 | - | - |
| IC50 | 3 | 6.27 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4213357 | — | — | 2 | 6.43 |
| CHEMBL4213793 | — | — | 2 | 6.31 |
| CHEMBL4208971 | — | — | 2 | 6.06 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4213357 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL4213793 | — | IC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4208971 | — | IC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4213357 | — | Imax | = | 88.0 | % | - |
| CHEMBL4208971 | — | Imax | = | 51.0 | % | - |
| CHEMBL4213793 | — | Imax | = | 55.0 | % | - |