Assay Detail
Binding
CHEMBL4194744
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRAF V600E mutant (unknown origin)
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase B-raf (CHEMBL5145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Current Insights of BRAF Inhibitors in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.14 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | 4.0 | 1 | 9.10 |
| CHEMBL3545027 | XL-281 | 2.0 | 1 | 8.22 |
| CHEMBL4204895 | — | — | 1 | 7.82 |
| CHEMBL4216588 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2028663 | DABRAFENIB | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL3545027 | XL-281 | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4204895 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4216588 | — | IC50 | = | 40.0 | nM | 7.40 |