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Assay Detail

CHEMBL4195120

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Binding
Binding affinity to histamine H1 receptor (unknown origin)
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Histamine H1 receptor (CHEMBL231)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system.
Pańczyk K, Pytka K, Jakubczyk M, Rapacz A, Sałat K, Furgała A, Siwek A, Głuch-Lutwin M, Gryboś A, Słoczyńska K, Pękala E, Żmudzki P, Bucki A, Kołaczkowski M, Żelaszczyk D, Marona H, Waszkielewicz AM.
Bioorg Med Chem Lett (2018) 28 : 2039 -2049
PubMed 29730027 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 8.70 8.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL896 HYDROXYZINE 4.0 1 8.70

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL896 HYDROXYZINE Ki = 2.0 nM 8.70