Assay Detail
Binding
CHEMBL4195136
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Displacement of [3H]methylspiperonee from recombinant human D2 receptor expressed in HEK293 cells cell membranes after 60 mins by liquid scintillation counting method
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and activity of di- or trisubstituted N-(phenoxyalkyl)- or N-{2-[2-(phenoxy)ethoxy]ethyl}piperazine derivatives on the central nervous system.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.64 | 8.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | 4.0 | 1 | 8.23 |
| CHEMBL4209888 | — | — | 1 | 7.01 |
| CHEMBL4213352 | — | — | 1 | 6.79 |
| CHEMBL4207653 | — | — | 1 | 6.72 |
| CHEMBL4212812 | — | — | 1 | 6.52 |
| CHEMBL4217761 | — | — | 1 | 5.92 |
| CHEMBL4205526 | — | — | 1 | 5.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL54 | HALOPERIDOL | Ki | = | 5.9 | nM | 8.23 |
| CHEMBL4209888 | — | Ki | = | 97.0 | nM | 7.01 |
| CHEMBL4213352 | — | Ki | = | 162.0 | nM | 6.79 |
| CHEMBL4207653 | — | Ki | = | 189.0 | nM | 6.72 |
| CHEMBL4212812 | — | Ki | = | 299.0 | nM | 6.52 |
| CHEMBL4217761 | — | Ki | = | 1206.0 | nM | 5.92 |
| CHEMBL4205526 | — | Ki | = | 4963.0 | nM | 5.30 |