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Assay Detail

CHEMBL4195643

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 48 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Intermediate

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

Lung cancer and matrix metalloproteinases inhibitors of polyphenols from Selaginella tamariscina with suppression activity of migration.
Wang CG, Yao WN, Zhang B, Hua J, Liang D, Wang HS.
Bioorg Med Chem Lett (2018) 28 : 2413 -2417
PubMed 29921475 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 4.75 5.50

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL273862 HYDROXYCAMPTOTHECIN 3.0 1 5.50
CHEMBL63354 AMENTOFLAVONE 1 5.04
CHEMBL4206592 1 4.81
CHEMBL63677 ROBUSTAFLAVONE 1 4.72
CHEMBL4211480 1 4.61
CHEMBL451902 1 4.58
CHEMBL4216342 1 4.55
CHEMBL3585679 1 4.52
CHEMBL4208646 1 4.46
CHEMBL4208066 1 -
CHEMBL4206956 1 -
CHEMBL4213048 1 -
CHEMBL378188 BILOBETIN 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL273862 HYDROXYCAMPTOTHECIN IC50 = 3190.0 nM 5.50
CHEMBL63354 AMENTOFLAVONE IC50 = 9130.0 nM 5.04
CHEMBL4206592 IC50 = 15380.0 nM 4.81
CHEMBL63677 ROBUSTAFLAVONE IC50 = 19150.0 nM 4.72
CHEMBL4211480 IC50 = 24770.0 nM 4.61
CHEMBL451902 IC50 = 26570.0 nM 4.58
CHEMBL4216342 IC50 = 28230.0 nM 4.55
CHEMBL3585679 IC50 = 30240.0 nM 4.52
CHEMBL4208646 IC50 = 34960.0 nM 4.46
CHEMBL4208066 IC50 > 50000.0 nM -
CHEMBL4206956 IC50 > 50000.0 nM -
CHEMBL4213048 IC50 > 50000.0 nM -
CHEMBL378188 BILOBETIN IC50 > 50000.0 nM -