Assay Detail
Functional
CHEMBL4195692
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HT-29 cells harboring BRAF V600E mutant after 24 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAFV600E inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 4.90 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209555 | — | — | 1 | 5.82 |
| CHEMBL4206547 | — | — | 1 | 5.66 |
| CHEMBL4211435 | — | — | 1 | 5.24 |
| CHEMBL4210074 | — | — | 1 | 5.21 |
| CHEMBL4217956 | — | — | 1 | 5.10 |
| CHEMBL4210104 | — | — | 1 | 5.07 |
| CHEMBL4213568 | — | — | 1 | 5.06 |
| CHEMBL4208630 | — | — | 1 | 5.03 |
| CHEMBL4215335 | — | — | 1 | 4.99 |
| CHEMBL4205709 | — | — | 1 | 4.97 |
| CHEMBL4205180 | — | — | 1 | 4.95 |
| CHEMBL4209989 | — | — | 1 | 4.94 |
| CHEMBL4218392 | — | — | 1 | 4.91 |
| CHEMBL4217416 | — | — | 1 | 4.90 |
| CHEMBL4203663 | — | — | 1 | 4.89 |
| CHEMBL4210916 | — | — | 1 | 4.89 |
| CHEMBL4215872 | — | — | 1 | 4.65 |
| CHEMBL4203142 | — | — | 1 | 4.62 |
| CHEMBL4208969 | — | — | 1 | 4.60 |
| CHEMBL4214559 | — | — | 1 | 4.59 |
| CHEMBL4208019 | — | — | 1 | 4.58 |
| CHEMBL4204094 | — | — | 1 | 4.57 |
| CHEMBL4205738 | — | — | 1 | 4.48 |
| CHEMBL4213026 | — | — | 1 | 4.46 |
| CHEMBL4211407 | — | — | 1 | 4.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209555 | — | IC50 | = | 1520.0 | nM | 5.82 |
| CHEMBL4206547 | — | IC50 | = | 2170.0 | nM | 5.66 |
| CHEMBL4211435 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL4210074 | — | IC50 | = | 6160.0 | nM | 5.21 |
| CHEMBL4217956 | — | IC50 | = | 7980.0 | nM | 5.10 |
| CHEMBL4210104 | — | IC50 | = | 8430.0 | nM | 5.07 |
| CHEMBL4213568 | — | IC50 | = | 8730.0 | nM | 5.06 |
| CHEMBL4208630 | — | IC50 | = | 9330.0 | nM | 5.03 |
| CHEMBL4215335 | — | IC50 | = | 10130.0 | nM | 4.99 |
| CHEMBL4205709 | — | IC50 | = | 10820.0 | nM | 4.97 |
| CHEMBL4205180 | — | IC50 | = | 11120.0 | nM | 4.95 |
| CHEMBL4209989 | — | IC50 | = | 11540.0 | nM | 4.94 |
| CHEMBL4218392 | — | IC50 | = | 12350.0 | nM | 4.91 |
| CHEMBL4217416 | — | IC50 | = | 12650.0 | nM | 4.90 |
| CHEMBL4203663 | — | IC50 | = | 12740.0 | nM | 4.89 |
| CHEMBL4210916 | — | IC50 | = | 12920.0 | nM | 4.89 |
| CHEMBL4215872 | — | IC50 | = | 22560.0 | nM | 4.65 |
| CHEMBL4203142 | — | IC50 | = | 24140.0 | nM | 4.62 |
| CHEMBL4208969 | — | IC50 | = | 25360.0 | nM | 4.60 |
| CHEMBL4214559 | — | IC50 | = | 25620.0 | nM | 4.59 |
| CHEMBL4208019 | — | IC50 | = | 26550.0 | nM | 4.58 |
| CHEMBL4204094 | — | IC50 | = | 26790.0 | nM | 4.57 |
| CHEMBL4205738 | — | IC50 | = | 32800.0 | nM | 4.48 |
| CHEMBL4213026 | — | IC50 | = | 35100.0 | nM | 4.46 |
| CHEMBL4211407 | — | IC50 | = | 49870.0 | nM | 4.30 |