Assay Detail
Functional
CHEMBL4196282
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity human MIAPaCa2 cells after 48 hrs by propidium iodide staining-based fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MIA PaCa-2 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.46 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.52 |
| CHEMBL4208224 | — | — | 1 | 6.52 |
| CHEMBL4213146 | — | — | 1 | 5.96 |
| CHEMBL4207316 | — | — | 1 | 5.89 |
| CHEMBL4208745 | — | — | 1 | 5.75 |
| CHEMBL4214496 | — | — | 1 | 5.58 |
| CHEMBL4209588 | — | — | 1 | 5.58 |
| CHEMBL4203868 | — | — | 1 | 5.34 |
| CHEMBL4213991 | — | — | 1 | 5.26 |
| CHEMBL4216082 | — | — | 1 | 5.08 |
| CHEMBL4215183 | — | — | 1 | 4.90 |
| CHEMBL4204413 | — | — | 1 | 4.86 |
| CHEMBL4218912 | — | — | 1 | 4.73 |
| CHEMBL4212603 | — | — | 1 | 4.47 |
| CHEMBL4205206 | — | — | 1 | 4.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4208224 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4213146 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4207316 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4208745 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4214496 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4209588 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4203868 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4213991 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4216082 | — | IC50 | = | 8300.0 | nM | 5.08 |
| CHEMBL4215183 | — | IC50 | = | 12500.0 | nM | 4.90 |
| CHEMBL4204413 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4218912 | — | IC50 | = | 18600.0 | nM | 4.73 |
| CHEMBL4212603 | — | IC50 | = | 33700.0 | nM | 4.47 |
| CHEMBL4205206 | — | IC50 | = | 36000.0 | nM | 4.44 |