Assay Detail
Functional
CHEMBL4196283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity human HT-29 cells after 48 hrs by propidium iodide staining-based fluorescence assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HT-29 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.47 | 7.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | 4.0 | 1 | 7.70 |
| CHEMBL4208224 | — | — | 1 | 6.22 |
| CHEMBL4208745 | — | — | 1 | 6.05 |
| CHEMBL4213146 | — | — | 1 | 6.05 |
| CHEMBL4207316 | — | — | 1 | 5.72 |
| CHEMBL4214496 | — | — | 1 | 5.62 |
| CHEMBL4209588 | — | — | 1 | 5.54 |
| CHEMBL4203868 | — | — | 1 | 5.32 |
| CHEMBL4213991 | — | — | 1 | 5.19 |
| CHEMBL4216082 | — | — | 1 | 5.11 |
| CHEMBL4215183 | — | — | 1 | 4.91 |
| CHEMBL4204413 | — | — | 1 | 4.86 |
| CHEMBL4218912 | — | — | 1 | 4.77 |
| CHEMBL4212603 | — | — | 1 | 4.56 |
| CHEMBL4205206 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL553 | ERLOTINIB | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4208224 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4208745 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4213146 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4207316 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4214496 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4209588 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4203868 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4213991 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4216082 | — | IC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4215183 | — | IC50 | = | 12200.0 | nM | 4.91 |
| CHEMBL4204413 | — | IC50 | = | 13800.0 | nM | 4.86 |
| CHEMBL4218912 | — | IC50 | = | 16900.0 | nM | 4.77 |
| CHEMBL4212603 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL4205206 | — | IC50 | = | 34700.0 | nM | 4.46 |