Assay Detail
Functional
CHEMBL4196290
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of ROS generation in human PMN after 50 mins by luminol-based chemiluminescence assay
29
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.07 | 5.83 |
| Inhibition | 14 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208224 | — | — | 2 | 5.83 |
| CHEMBL4208745 | — | — | 2 | 5.47 |
| CHEMBL4209588 | — | — | 2 | 5.23 |
| CHEMBL4203868 | — | — | 2 | 5.19 |
| CHEMBL4213146 | — | — | 2 | 5.18 |
| CHEMBL4212603 | — | — | 2 | 5.11 |
| CHEMBL4207316 | — | — | 2 | 5.01 |
| CHEMBL25 | ASPIRIN | 4.0 | 1 | 5.01 |
| CHEMBL4213991 | — | — | 2 | 4.97 |
| CHEMBL4214496 | — | — | 2 | 4.95 |
| CHEMBL4205206 | — | — | 2 | 4.93 |
| CHEMBL4215183 | — | — | 2 | 4.88 |
| CHEMBL4216082 | — | — | 2 | 4.86 |
| CHEMBL4204413 | — | — | 2 | 4.72 |
| CHEMBL4218912 | — | — | 2 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208224 | — | IC50 | = | 1480.0 | nM | 5.83 |
| CHEMBL4208745 | — | IC50 | = | 3360.0 | nM | 5.47 |
| CHEMBL4209588 | — | IC50 | = | 5910.0 | nM | 5.23 |
| CHEMBL4203868 | — | IC50 | = | 6440.0 | nM | 5.19 |
| CHEMBL4213146 | — | IC50 | = | 6530.0 | nM | 5.18 |
| CHEMBL4212603 | — | IC50 | = | 7770.0 | nM | 5.11 |
| CHEMBL25 | ASPIRIN | IC50 | = | 9780.0 | nM | 5.01 |
| CHEMBL4207316 | — | IC50 | = | 9700.0 | nM | 5.01 |
| CHEMBL4213991 | — | IC50 | = | 10610.0 | nM | 4.97 |
| CHEMBL4214496 | — | IC50 | = | 11330.0 | nM | 4.95 |
| CHEMBL4205206 | — | IC50 | = | 11850.0 | nM | 4.93 |
| CHEMBL4215183 | — | IC50 | = | 13030.0 | nM | 4.88 |
| CHEMBL4216082 | — | IC50 | = | 13810.0 | nM | 4.86 |
| CHEMBL4204413 | — | IC50 | = | 19030.0 | nM | 4.72 |
| CHEMBL4218912 | — | IC50 | = | 23060.0 | nM | 4.64 |
| CHEMBL4216082 | — | Inhibition | - | % | - | |
| CHEMBL4218912 | — | Inhibition | - | % | - | |
| CHEMBL4213991 | — | Inhibition | - | % | - | |
| CHEMBL4214496 | — | Inhibition | - | % | - | |
| CHEMBL4209588 | — | Inhibition | - | % | - | |
| CHEMBL4207316 | — | Inhibition | - | % | - | |
| CHEMBL4205206 | — | Inhibition | - | % | - | |
| CHEMBL4213146 | — | Inhibition | - | % | - | |
| CHEMBL4204413 | — | Inhibition | - | % | - | |
| CHEMBL4203868 | — | Inhibition | - | % | - | |
| CHEMBL4208745 | — | Inhibition | - | % | - | |
| CHEMBL4208224 | — | Inhibition | - | % | - | |
| CHEMBL4215183 | — | Inhibition | - | % | - | |
| CHEMBL4212603 | — | Inhibition | - | % | - |