Assay Detail

CHEMBL4197178

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Functional

Induction of proton motive force collapse in Escherichia coli inverted membrane vesicle in presence of ATP-driven PMF generation system by ACMA-based fluorescence assay

ChEMBL ↗

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Target

Unchecked (CHEMBL612545) ↗

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Unchecked (CHEMBL612545) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target Unchecked

CHEMBL612545

Anchored from Assay target.

Protein identity Unchecked

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Escherichia coli
Confidence	0 — Uncurated / Unknown
Curated By	Autocuration

Target

Unchecked (CHEMBL612545) ↗

Type

UNCHECKED

Publication

Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS.
Eur J Med Chem (2018) 148 : 195 -209
PubMed 29459278 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
EC50	2	5.48	6.33

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL224214	CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE	—	1	6.33
CHEMBL4214440	—	—	1	4.62

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL224214	CARBONYL CYANIDE M-CHLOROPHENYLHYDRAZONE	EC50	=	470.0	nM	6.33
CHEMBL4214440	—	EC50	=	24000.0	nM	4.62