Assay Detail
ADMET
CHEMBL4197221
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Antiproliferative activity against human A549 cells harboring wild type EGFR after 72 hrs by MTT assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of 2,4,6-trisubstitued pyrido[3,4-d]pyrimidine derivatives as new EGFR-TKIs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 6.06 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204139 | — | — | 1 | 6.38 |
| CHEMBL3353410 | OSIMERTINIB | 4.0 | 1 | 6.28 |
| CHEMBL4215076 | — | — | 1 | 6.28 |
| CHEMBL4203016 | — | — | 1 | 6.27 |
| CHEMBL4217992 | — | — | 1 | 6.26 |
| CHEMBL4208673 | — | — | 1 | 6.22 |
| CHEMBL4206166 | — | — | 1 | 6.16 |
| CHEMBL4203001 | — | — | 1 | 6.16 |
| CHEMBL4212884 | — | — | 1 | 6.13 |
| CHEMBL4205781 | — | — | 1 | 6.13 |
| CHEMBL4204983 | — | — | 1 | 6.08 |
| CHEMBL4210148 | — | — | 1 | 6.01 |
| CHEMBL4206288 | — | — | 1 | 5.99 |
| CHEMBL4209019 | — | — | 1 | 5.97 |
| CHEMBL4215080 | — | — | 1 | 5.94 |
| CHEMBL4213057 | — | — | 1 | 5.89 |
| CHEMBL4206716 | — | — | 1 | 5.88 |
| CHEMBL4209801 | — | — | 1 | 5.06 |
| CHEMBL4207246 | — | — | 1 | - |
| CHEMBL4210648 | — | — | 1 | - |
| CHEMBL4215795 | — | — | 1 | - |
| CHEMBL4210481 | — | — | 1 | - |
| CHEMBL4205095 | — | — | 1 | - |
| CHEMBL4204750 | — | — | 1 | - |
| CHEMBL4207952 | — | — | 1 | - |
| CHEMBL4214664 | — | — | 1 | - |
| CHEMBL4218311 | — | — | 1 | - |
| CHEMBL4213899 | — | — | 1 | - |
| CHEMBL4206552 | — | — | 1 | - |
| CHEMBL4211799 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204139 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL3353410 | OSIMERTINIB | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4215076 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL4203016 | — | IC50 | = | 540.0 | nM | 6.27 |
| CHEMBL4217992 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL4208673 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4206166 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4203001 | — | IC50 | = | 690.0 | nM | 6.16 |
| CHEMBL4212884 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4205781 | — | IC50 | = | 740.0 | nM | 6.13 |
| CHEMBL4204983 | — | IC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4210148 | — | IC50 | = | 970.0 | nM | 6.01 |
| CHEMBL4206288 | — | IC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4209019 | — | IC50 | = | 1060.0 | nM | 5.97 |
| CHEMBL4215080 | — | IC50 | = | 1140.0 | nM | 5.94 |
| CHEMBL4213057 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4206716 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL4209801 | — | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL4218311 | — | IC50 | - | — | - | |
| CHEMBL4213724 | — | IC50 | - | — | - | |
| CHEMBL4208877 | — | IC50 | - | — | - | |
| CHEMBL4203541 | — | IC50 | - | — | - | |
| CHEMBL4207249 | — | IC50 | - | — | - | |
| CHEMBL4215582 | — | IC50 | - | — | - | |
| CHEMBL4211799 | — | IC50 | - | — | - | |
| CHEMBL4206552 | — | IC50 | - | — | - | |
| CHEMBL4213899 | — | IC50 | - | — | - | |
| CHEMBL4207246 | — | IC50 | - | — | - | |
| CHEMBL4214664 | — | IC50 | - | — | - | |
| CHEMBL4207952 | — | IC50 | - | — | - | |
| CHEMBL4204750 | — | IC50 | - | — | - | |
| CHEMBL4205095 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4210481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4215795 | — | IC50 | - | — | - | |
| CHEMBL4210648 | — | IC50 | - | — | - |