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Assay Detail

CHEMBL4197477

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Functional
Antiproliferative activity against human MCF7 cells after 72 hrs by MTT assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MCF7
Confidence 1 — Organism
Curated By Intermediate

Target

MCF7 (CHEMBL387)
Type CELL-LINE
Organism Homo sapiens

Publication

Potent hydrazone derivatives targeting esophageal cancer cells.
Li LY, Peng JD, Zhou W, Qiao H, Deng X, Li ZH, Li JD, Fu YD, Li S, Sun K, Liu HM, Zhao W.
Eur J Med Chem (2018) 148 : 359 -371
PubMed 29475156 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 21 5.04 6.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4216351 1 6.00
CHEMBL1979784 1 5.45
CHEMBL4204953 1 5.29
CHEMBL3104350 1 5.27
CHEMBL4210327 1 5.18
CHEMBL4218925 1 5.11
CHEMBL3196184 1 4.79
CHEMBL4212776 1 4.78
CHEMBL185 FLUOROURACIL 4.0 1 4.73
CHEMBL4216637 1 4.71
CHEMBL4209263 1 4.57
CHEMBL4202577 1 4.54
CHEMBL4204825 1 -
CHEMBL4204312 1 -
CHEMBL4209177 1 -
CHEMBL4203025 1 -
CHEMBL3191702 1 -
CHEMBL4217967 1 -
CHEMBL4203492 1 -
CHEMBL4207390 1 -
CHEMBL4213185 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4216351 IC50 = 1010.0 nM 6.00
CHEMBL1979784 IC50 = 3520.0 nM 5.45
CHEMBL4204953 IC50 = 5140.0 nM 5.29
CHEMBL3104350 IC50 = 5400.0 nM 5.27
CHEMBL4210327 IC50 = 6650.0 nM 5.18
CHEMBL4218925 IC50 = 7830.0 nM 5.11
CHEMBL3196184 IC50 = 16030.0 nM 4.79
CHEMBL4212776 IC50 = 16450.0 nM 4.78
CHEMBL185 FLUOROURACIL IC50 = 18750.0 nM 4.73
CHEMBL4216637 IC50 = 19280.0 nM 4.71
CHEMBL4209263 IC50 = 26640.0 nM 4.57
CHEMBL4202577 IC50 = 29130.0 nM 4.54
CHEMBL4204825 IC50 > 100000.0 nM -
CHEMBL4204312 IC50 > 100000.0 nM -
CHEMBL4209177 IC50 > 100000.0 nM -
CHEMBL4203025 IC50 > 100000.0 nM -
CHEMBL3191702 IC50 > 100000.0 nM -
CHEMBL4217967 IC50 > 100000.0 nM -
CHEMBL4203492 IC50 > 100000.0 nM -
CHEMBL4207390 IC50 > 100000.0 nM -
CHEMBL4213185 IC50 > 100000.0 nM -