Assay Detail

CHEMBL4197696

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Binding

Inhibition of human gamma-secretase

ChEMBL ↗

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Target

Gamma-secretase (CHEMBL2094135) ↗

Open DB target context

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Primary target Gamma-secretase

CHEMBL2094135

Anchored from Assay target.

Protein identity Gamma-secretase

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Homo sapiens
Confidence	7 — Homologous single protein target
Curated By	Intermediate

Target

Gamma-secretase (CHEMBL2094135) ↗

Type	PROTEIN COMPLEX
Organism	Homo sapiens

Publication

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.

Kumar D, Ganeshpurkar A, Kumar D, Modi G, Gupta SK, Singh SK.
Eur J Med Chem (2018) 148 : 436 -452
PubMed 29477076 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	8.21	8.21

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL1770916	NIROGACESTAT	4.0	1	8.21

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL1770916	NIROGACESTAT	IC50	=	6.2	nM	8.21