Assay Detail
Binding
CHEMBL4197704
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse modulatory activity at gamma-secretase (unknown origin) assessed as increase in amyloid beta (1 to 42) level
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.23 | 5.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL429432 | URSOCHOLANIC ACID | — | 1 | 5.25 |
| CHEMBL4215431 | — | — | 1 | 5.20 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL429432 | URSOCHOLANIC ACID | IC50 | = | 5680.0 | nM | 5.25 |
| CHEMBL4215431 | — | IC50 | = | 6250.0 | nM | 5.20 |