Assay Detail
Binding
CHEMBL4197757
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human MAO-B expressed in baculovirus infected insect cell membranes using kynuramine as substrate after 15 to 20 mins by discontinuous fluorimetric method
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel indanone derivatives as MAO B/H3R dual-targeting ligands for treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.36 | 7.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | 4.0 | 1 | 7.38 |
| CHEMBL396778 | SAFINAMIDE | 4.0 | 1 | 7.28 |
| CHEMBL4205653 | — | — | 1 | 6.56 |
| CHEMBL4217355 | — | — | 1 | 5.84 |
| CHEMBL4218833 | — | — | 1 | 5.71 |
| CHEMBL2297871 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL972 | SELEGILINE | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL396778 | SAFINAMIDE | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL4205653 | — | IC50 | = | 276.0 | nM | 6.56 |
| CHEMBL4217355 | — | IC50 | = | 1455.0 | nM | 5.84 |
| CHEMBL4218833 | — | IC50 | = | 1931.0 | nM | 5.71 |
| CHEMBL2297871 | — | IC50 | = | 3884.0 | nM | 5.41 |