Assay Detail
Functional
CHEMBL4197876
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Inhibition of smo-mediated hedgehog signaling pathway in mouse NIH3T3 cells expressing GRE-Luc reporter gene assessed as inhibition of SAG-induced GRE-Luc reporter activity after 48 hrs by luminescence assay
6
Total Activities
5
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | NIH3T3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and characterization of a potent Wnt and hedgehog signaling pathways dual inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.68 | 8.22 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | 4.0 | 1 | 8.22 |
| CHEMBL3972086 | — | — | 2 | 7.15 |
| CHEMBL4215992 | — | — | 1 | 5.91 |
| CHEMBL4215124 | — | — | 1 | 5.44 |
| CHEMBL3188386 | WNT-974 | 2.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL473417 | VISMODEGIB | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL3972086 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4215992 | — | IC50 | = | 1223.0 | nM | 5.91 |
| CHEMBL4215124 | — | IC50 | = | 3661.0 | nM | 5.44 |
| CHEMBL3188386 | WNT-974 | Inhibition | - | % | - | |
| CHEMBL3972086 | — | Inhibition | - | % | - |