Assay Detail
Binding
CHEMBL4197966
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Inhibition of recombinant West Nile virus NS2B-NS3 protease using pERTKR-AMC as substrate preincubated for 30 mins followed by substrate addition by fluorescence assay
4
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | West Nile virus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Zirconium catalyzed synthesis of 2-arylidene Indan-1,3-diones and evaluation of their inhibitory activity against NS2B-NS3 WNV protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.24 | 5.52 |
| Inhibition | 2 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL83598 | — | — | 2 | 5.52 |
| CHEMBL3275868 | — | — | 2 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL83598 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL3275868 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL3275868 | — | Inhibition | - | % | - | |
| CHEMBL83598 | — | Inhibition | - | % | - |