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Assay Detail

CHEMBL4197997

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Functional
Antiproliferative activity against human HeLa cells after 48 hrs by MTT assay
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type HeLa
Confidence 1 — Organism
Curated By Intermediate

Target

HeLa (CHEMBL399)
Type CELL-LINE
Organism Homo sapiens

Publication

Synthesis and biological evaluation of Schizandrin derivatives as potential anti-cancer agents.
Amujuri D, Siva B, Poornima B, Sirisha K, Sarma AVS, Lakshma Nayak V, Tiwari AK, Purushotham U, Suresh Babu K.
Eur J Med Chem (2018) 149 : 182 -192
PubMed 29501940 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 16 4.69 5.70

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL53463 DOXORUBICIN 4.0 1 5.70
CHEMBL4215906 1 5.63
CHEMBL4210350 1 4.92
CHEMBL4204246 1 4.89
CHEMBL4208577 1 4.78
CHEMBL4202760 1 4.68
CHEMBL4216441 1 4.68
CHEMBL4214408 1 4.62
CHEMBL4203169 1 4.62
CHEMBL253688 SCHIZANDRIN 1 4.54
CHEMBL4211472 1 4.46
CHEMBL4203698 1 4.29
CHEMBL4202748 1 4.26
CHEMBL4207110 1 4.16
CHEMBL4208044 1 4.14
CHEMBL4207624 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL53463 DOXORUBICIN IC50 = 1995.0 nM 5.70
CHEMBL4215906 IC50 = 2328.0 nM 5.63
CHEMBL4210350 IC50 = 11960.0 nM 4.92
CHEMBL4204246 IC50 = 12790.0 nM 4.89
CHEMBL4208577 IC50 = 16580.0 nM 4.78
CHEMBL4202760 IC50 = 20750.0 nM 4.68
CHEMBL4216441 IC50 = 20740.0 nM 4.68
CHEMBL4214408 IC50 = 23840.0 nM 4.62
CHEMBL4203169 IC50 = 23860.0 nM 4.62
CHEMBL253688 SCHIZANDRIN IC50 = 28560.0 nM 4.54
CHEMBL4211472 IC50 = 34290.0 nM 4.46
CHEMBL4203698 IC50 = 51440.0 nM 4.29
CHEMBL4202748 IC50 = 55000.0 nM 4.26
CHEMBL4207110 IC50 = 69570.0 nM 4.16
CHEMBL4208044 IC50 = 71600.0 nM 4.14
CHEMBL4207624 IC50 = 123900.0 nM -