Assay Detail
Functional
CHEMBL4198047
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Growth inhibition of human WM164 cells after 72 hrs by MTS assay
35
Total Activities
35
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | WM164 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 35 | 5.43 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214373 | — | — | 1 | 6.16 |
| CHEMBL4204700 | — | — | 1 | 6.16 |
| CHEMBL4207064 | — | — | 1 | 6.16 |
| CHEMBL4205613 | — | — | 1 | 6.16 |
| CHEMBL4209981 | — | — | 1 | 6.10 |
| CHEMBL4202712 | — | — | 1 | 6.05 |
| CHEMBL4210971 | — | — | 1 | 6.05 |
| CHEMBL4213303 | — | — | 1 | 6.05 |
| CHEMBL4210483 | — | — | 1 | 5.96 |
| CHEMBL4215928 | — | — | 1 | 5.96 |
| CHEMBL4218793 | — | — | 1 | 5.85 |
| CHEMBL4208723 | — | — | 1 | 5.80 |
| CHEMBL4209565 | — | — | 1 | 5.72 |
| CHEMBL4203845 | — | — | 1 | 5.55 |
| CHEMBL4212145 | — | — | 1 | 5.43 |
| CHEMBL4212759 | — | — | 1 | 5.35 |
| CHEMBL4205470 | — | — | 1 | 5.34 |
| CHEMBL4214895 | — | — | 1 | 5.33 |
| CHEMBL4208078 | — | — | 1 | 5.19 |
| CHEMBL4203204 | — | — | 1 | 5.16 |
| CHEMBL4204974 | — | — | 1 | 5.15 |
| CHEMBL4203716 | — | — | 1 | 5.12 |
| CHEMBL4217188 | — | — | 1 | 5.07 |
| CHEMBL4215109 | — | — | 1 | 5.07 |
| CHEMBL4215393 | — | — | 1 | 5.05 |
| CHEMBL4209848 | — | — | 1 | 4.94 |
| CHEMBL4207259 | — | — | 1 | 4.89 |
| CHEMBL4217711 | — | — | 1 | 4.78 |
| CHEMBL4211490 | — | — | 1 | 4.70 |
| CHEMBL4207127 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214373 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4205613 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4207064 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4204700 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4209981 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4202712 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4210971 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4213303 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4210483 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4215928 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4218793 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL4208723 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4209565 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4203845 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL4212145 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL4212759 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL4205470 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4214895 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4208078 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4203204 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4204974 | — | IC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4203716 | — | IC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL4217188 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL4215109 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL4215393 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4209848 | — | IC50 | = | 11500.0 | nM | 4.94 |
| CHEMBL4207259 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL4217711 | — | IC50 | = | 16700.0 | nM | 4.78 |
| CHEMBL4211490 | — | IC50 | = | 20180.0 | nM | 4.70 |
| CHEMBL4207127 | — | IC50 | = | 24900.0 | nM | 4.60 |
| CHEMBL4216591 | — | IC50 | = | 33900.0 | nM | 4.47 |
| CHEMBL4211611 | — | IC50 | = | 56400.0 | nM | 4.25 |
| CHEMBL4203443 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4218858 | — | IC50 | - | — | - | |
| CHEMBL4206599 | — | IC50 | - | — | - |