Assay Detail
Functional
CHEMBL4198053
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Cytotoxicity against human KB-C2 cells assessed as reduction in cell viability after 72 hrs by MTT assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of indole-based UC-112 analogs as potent and selective survivin inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.22 | 6.77 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205613 | — | — | 1 | 6.77 |
| CHEMBL4209981 | — | — | 1 | 6.75 |
| CHEMBL4202712 | — | — | 1 | 6.60 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 6.60 |
| CHEMBL4215928 | — | — | 1 | 6.48 |
| CHEMBL4204700 | — | — | 1 | 6.36 |
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 5.77 |
| CHEMBL4208369 | — | — | 1 | 4.43 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205613 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4209981 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL4202712 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4215928 | — | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL4204700 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 1690.0 | nM | 5.77 |
| CHEMBL4208369 | — | IC50 | = | 37300.0 | nM | 4.43 |