Assay Detail
Functional
CHEMBL4198286
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Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 5.55 | 7.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL19980 | BREFELDIN A | — | 1 | 7.62 |
| CHEMBL4209689 | — | — | 1 | 6.60 |
| CHEMBL4214089 | — | — | 1 | 5.86 |
| CHEMBL4204819 | — | — | 1 | 5.84 |
| CHEMBL4209168 | — | — | 1 | 5.83 |
| CHEMBL4207002 | — | — | 1 | 5.71 |
| CHEMBL4218504 | — | — | 1 | 5.31 |
| CHEMBL4210604 | — | — | 1 | 5.31 |
| CHEMBL4205312 | — | — | 1 | 5.20 |
| CHEMBL4213570 | — | — | 1 | 5.14 |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | 4.73 |
| CHEMBL4062886 | — | — | 1 | 4.62 |
| CHEMBL12293 | — | — | 1 | 4.33 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL19980 | BREFELDIN A | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4209689 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4214089 | — | IC50 | = | 1370.0 | nM | 5.86 |
| CHEMBL4204819 | — | IC50 | = | 1450.0 | nM | 5.84 |
| CHEMBL4209168 | — | IC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4207002 | — | IC50 | = | 1930.0 | nM | 5.71 |
| CHEMBL4218504 | — | IC50 | = | 4860.0 | nM | 5.31 |
| CHEMBL4210604 | — | IC50 | = | 4850.0 | nM | 5.31 |
| CHEMBL4205312 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4213570 | — | IC50 | = | 7250.0 | nM | 5.14 |
| CHEMBL185 | FLUOROURACIL | IC50 | = | 18490.0 | nM | 4.73 |
| CHEMBL4062886 | — | IC50 | = | 23940.0 | nM | 4.62 |
| CHEMBL12293 | — | IC50 | = | 46450.0 | nM | 4.33 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 80000.0 | nM | - |