Assay Detail
ADMET
CHEMBL4198288
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Antiproliferative activity against human LO2 cells after 72 hrs by MTT assay
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Cell Type | L02 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Novel hybrids of brefeldin A and nitrogen mustards with improved antiproliferative selectivity: Design, synthesis and antitumor biological evaluation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 4.79 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209168 | — | — | 1 | 5.34 |
| CHEMBL4214089 | — | — | 1 | 5.29 |
| CHEMBL4204819 | — | — | 1 | 5.02 |
| CHEMBL4209689 | — | — | 1 | 5.01 |
| CHEMBL4218504 | — | — | 1 | 4.81 |
| CHEMBL4205312 | — | — | 1 | 4.76 |
| CHEMBL4213570 | — | — | 1 | 4.71 |
| CHEMBL4207002 | — | — | 1 | 4.53 |
| CHEMBL4210604 | — | — | 1 | 4.53 |
| CHEMBL4062886 | — | — | 1 | 4.48 |
| CHEMBL12293 | — | — | 1 | 4.16 |
| CHEMBL515 | CHLORAMBUCIL | 4.0 | 1 | - |
| CHEMBL19980 | BREFELDIN A | — | 1 | - |
| CHEMBL185 | FLUOROURACIL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209168 | — | IC50 | = | 4570.0 | nM | 5.34 |
| CHEMBL4214089 | — | IC50 | = | 5160.0 | nM | 5.29 |
| CHEMBL4204819 | — | IC50 | = | 9510.0 | nM | 5.02 |
| CHEMBL4209689 | — | IC50 | = | 9740.0 | nM | 5.01 |
| CHEMBL4218504 | — | IC50 | = | 15470.0 | nM | 4.81 |
| CHEMBL4205312 | — | IC50 | = | 17320.0 | nM | 4.76 |
| CHEMBL4213570 | — | IC50 | = | 19470.0 | nM | 4.71 |
| CHEMBL4207002 | — | IC50 | = | 29580.0 | nM | 4.53 |
| CHEMBL4210604 | — | IC50 | = | 29870.0 | nM | 4.53 |
| CHEMBL4062886 | — | IC50 | = | 32860.0 | nM | 4.48 |
| CHEMBL12293 | — | IC50 | = | 68570.0 | nM | 4.16 |
| CHEMBL515 | CHLORAMBUCIL | IC50 | > | 80000.0 | nM | - |
| CHEMBL19980 | BREFELDIN A | IC50 | < | 1.0 | nM | - |
| CHEMBL185 | FLUOROURACIL | IC50 | - | — | - |