Assay Detail
ADMET
CHEMBL4198677
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Inhibition of HDAC6 (unknown origin) using Boc-Lys(acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition measured after 30 mins by fluorescence assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of meta-sulfamoyl N-hydroxybenzamides as HDAC8 selective inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.23 | 7.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.05 |
| CHEMBL4206936 | — | — | 1 | 5.82 |
| CHEMBL4218377 | — | — | 1 | 5.75 |
| CHEMBL4218674 | — | — | 1 | 5.58 |
| CHEMBL4214401 | — | — | 1 | 5.23 |
| CHEMBL4210091 | — | — | 1 | 5.17 |
| CHEMBL4206647 | — | — | 1 | 4.85 |
| CHEMBL4211116 | — | — | 1 | 4.61 |
| CHEMBL4213975 | — | — | 1 | 4.56 |
| CHEMBL4202721 | — | — | 1 | 4.47 |
| CHEMBL4218901 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL98 | VORINOSTAT | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL4206936 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4218377 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4218674 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4214401 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL4210091 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL4206647 | — | IC50 | = | 14100.0 | nM | 4.85 |
| CHEMBL4211116 | — | IC50 | = | 24500.0 | nM | 4.61 |
| CHEMBL4213975 | — | IC50 | = | 27700.0 | nM | 4.56 |
| CHEMBL4202721 | — | IC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL4218901 | — | IC50 | = | 40500.0 | nM | 4.39 |