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Assay Detail

CHEMBL4198701

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 24 hrs by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Organism Homo sapiens
Cell Type HepG2
Confidence 1 — Organism
Curated By Intermediate

Target

HepG2 (CHEMBL395)
Type CELL-LINE
Organism Homo sapiens

Publication

The concept of hybrid molecules of tacrine and benzyl quinolone carboxylic acid (BQCA) as multifunctional agents for Alzheimer's disease.
Hepnarova V, Korabecny J, Matouskova L, Jost P, Muckova L, Hrabinova M, Vykoukalova N, Kerhartova M, Kucera T, Dolezal R, Nepovimova E, Spilovska K, Mezeiova E, Pham NL, Jun D, Staud F, Kaping D, Kuca K, Soukup O.
Eur J Med Chem (2018) 150 : 292 -306
PubMed 29533874 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 13 5.42 6.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4217617 1 6.22
CHEMBL4205374 1 5.84
CHEMBL4212151 1 5.79
CHEMBL4214668 1 5.66
CHEMBL4217126 1 5.62
CHEMBL4206484 1 5.57
CHEMBL4215217 1 5.46
CHEMBL4210729 1 5.30
CHEMBL292314 1 4.37
CHEMBL1256415 1 4.35
CHEMBL95 TACRINE 4.0 1 -
CHEMBL608112 1 -
CHEMBL4213591 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4217617 IC50 = 600.0 nM 6.22
CHEMBL4205374 IC50 = 1440.0 nM 5.84
CHEMBL4212151 IC50 = 1630.0 nM 5.79
CHEMBL4214668 IC50 = 2170.0 nM 5.66
CHEMBL4217126 IC50 = 2420.0 nM 5.62
CHEMBL4206484 IC50 = 2720.0 nM 5.57
CHEMBL4215217 IC50 = 3480.0 nM 5.46
CHEMBL4210729 IC50 = 4990.0 nM 5.30
CHEMBL292314 IC50 = 43200.0 nM 4.37
CHEMBL1256415 IC50 = 44370.0 nM 4.35
CHEMBL95 TACRINE IC50 = 168470.0 nM -
CHEMBL608112 IC50 > 40000.0 nM -
CHEMBL4213591 IC50 > 40000.0 nM -