Assay Detail
Binding
CHEMBL4198707
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Inhibition of Feline infectious peritonitis virus 3CL protease using Dabcyl-KTSAVLQ/SGFRKME-Edans as substrate incubated for 30 mins followed by substrate addition measured after 1 hr by FRET assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Feline infectious peritonitis virus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Replicase polyprotein 1ab (CHEMBL4295624) ↗| Type | SINGLE PROTEIN |
| Organism | Feline coronavirus (strain FIPV WSU-79/1146) (FCoV) |
Publication
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 5.72 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214066 | — | — | 1 | 6.10 |
| CHEMBL4214471 | — | — | 1 | 6.10 |
| CHEMBL4208764 | — | — | 1 | 5.96 |
| CHEMBL4204431 | — | — | 1 | 5.96 |
| CHEMBL4217568 | — | — | 1 | 5.89 |
| CHEMBL4202812 | — | — | 1 | 5.80 |
| CHEMBL4203883 | — | — | 1 | 5.68 |
| CHEMBL4213159 | — | — | 1 | 5.64 |
| CHEMBL4208240 | — | — | 1 | 5.62 |
| CHEMBL4209146 | — | — | 1 | 5.46 |
| CHEMBL4212620 | — | — | 1 | 5.26 |
| CHEMBL4216101 | — | — | 1 | 5.17 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214066 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4214471 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4208764 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4204431 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL4217568 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL4202812 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL4203883 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL4213159 | — | IC50 | = | 2300.0 | nM | 5.64 |
| CHEMBL4208240 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4209146 | — | IC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL4212620 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL4216101 | — | IC50 | = | 6700.0 | nM | 5.17 |