Assay Detail
Functional
CHEMBL4198709
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS coronavirus infected in cat CRFK cells assessed as reduction in viral titer after 48 hrs
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome-related coronavirus |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Target
SARS-CoV (CHEMBL4303836) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome-related coronavirus |
Publication
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 2 | 6.11 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4208240 | — | — | 1 | 6.22 |
| CHEMBL4203883 | — | — | 1 | 6.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4208240 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4203883 | — | EC50 | = | 1000.0 | nM | 6.00 |