Assay Detail
Binding
CHEMBL4198899
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Inhibition of HDAC6 (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.44 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | — | 1 | 8.40 |
| CHEMBL2364628 | RICOLINOSTAT | 2.0 | 1 | 8.33 |
| CHEMBL2018302 | TUBASTATIN A | — | 1 | 7.82 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 7.42 |
| CHEMBL4066043 | — | — | 1 | 7.25 |
| CHEMBL4208487 | — | — | 1 | 6.96 |
| CHEMBL99 | TRICHOSTATIN | 1.0 | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL356769 | TUBACIN | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL2364628 | RICOLINOSTAT | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL2018302 | TUBASTATIN A | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4066043 | — | IC50 | = | 56.0 | nM | 7.25 |
| CHEMBL4208487 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL99 | TRICHOSTATIN | IC50 | = | 1210.0 | nM | 5.92 |