Assay Detail
Binding
CHEMBL4199267
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Binding affinity to 5-HT7 receptor (unknown origin)
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships and Therapeutic Potentials of 5-HT7 Receptor Ligands: An Update.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 8 | 8.39 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4216782 | — | — | 1 | 9.33 |
| CHEMBL2164327 | — | — | 1 | 9.22 |
| CHEMBL18840 | — | — | 1 | 9.03 |
| CHEMBL69257 | — | — | 1 | 8.67 |
| CHEMBL4205349 | — | — | 1 | 8.60 |
| CHEMBL4211987 | — | — | 1 | 8.40 |
| CHEMBL12264 | SB-258719 | — | 1 | 7.50 |
| CHEMBL273273 | 5-OH-DPAT | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4216782 | — | Ki | = | 0.47 | nM | 9.33 |
| CHEMBL2164327 | — | Ki | = | 0.6 | nM | 9.22 |
| CHEMBL18840 | — | Ki | = | 0.93 | nM | 9.03 |
| CHEMBL69257 | — | Ki | = | 2.14 | nM | 8.67 |
| CHEMBL4205349 | — | Ki | = | 2.5 | nM | 8.60 |
| CHEMBL4211987 | — | Ki | = | 4.0 | nM | 8.40 |
| CHEMBL12264 | SB-258719 | Ki | = | 31.6 | nM | 7.50 |
| CHEMBL273273 | 5-OH-DPAT | Ki | = | 466.0 | nM | 6.33 |