Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4199503

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of ITK (unknown origin) using fluorescently labeled peptide as substrate after 3 hrs by microfluidic mobility shift assay
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Tyrosine-protein kinase ITK/TSK (CHEMBL2959)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Covalent Inhibitors of the TEC Family of Kinases and Their Methods of Use.
Blass BE.
ACS Med Chem Lett (2018) 9 : 587 -589
PubMed 30034582 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 8.99 9.47

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4203077 1 9.47
CHEMBL4219011 1 9.39
CHEMBL4206765 1 9.28
CHEMBL4214683 1 9.24
CHEMBL4216529 1 9.19
CHEMBL4207292 1 9.17
CHEMBL4215147 1 9.15
CHEMBL4216187 1 9.14
CHEMBL4211372 1 9.09
CHEMBL4202941 1 9.06
CHEMBL4217959 1 9.04
CHEMBL4208358 1 9.00
CHEMBL4218914 1 8.82
CHEMBL4210857 1 8.82
CHEMBL4215807 1 8.79
CHEMBL4204572 1 8.66
CHEMBL4206487 1 8.49
CHEMBL4202618 1 8.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4203077 IC50 = 0.34 nM 9.47
CHEMBL4219011 IC50 = 0.41 nM 9.39
CHEMBL4206765 IC50 = 0.53 nM 9.28
CHEMBL4214683 IC50 = 0.58 nM 9.24
CHEMBL4216529 IC50 = 0.64 nM 9.19
CHEMBL4207292 IC50 = 0.67 nM 9.17
CHEMBL4215147 IC50 = 0.7 nM 9.15
CHEMBL4216187 IC50 = 0.72 nM 9.14
CHEMBL4211372 IC50 = 0.81 nM 9.09
CHEMBL4202941 IC50 = 0.87 nM 9.06
CHEMBL4217959 IC50 = 0.92 nM 9.04
CHEMBL4208358 IC50 = 0.99 nM 9.00
CHEMBL4218914 IC50 = 1.52 nM 8.82
CHEMBL4210857 IC50 = 1.5 nM 8.82
CHEMBL4215807 IC50 = 1.62 nM 8.79
CHEMBL4204572 IC50 = 2.17 nM 8.66
CHEMBL4206487 IC50 = 3.23 nM 8.49
CHEMBL4202618 IC50 = 10.1 nM 8.00