Assay Detail
Binding
CHEMBL4199510
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of sPLA2-2A (unknown origin) using 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine as substrate pretreated for 20 mins followed by substrate addition and measured after 60 mins by NEFA based assay
22
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phospholipase A2, membrane associated (CHEMBL3474) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design of Selective sPLA2-X Inhibitor (-)-2-{2-[Carbamoyl-6-(trifluoromethoxy)-1H-indol-1-yl]pyridine-2-yl}propanoic Acid.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 6.17 | 7.36 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205008 | — | — | 2 | 7.36 |
| CHEMBL4214052 | — | — | 2 | 7.24 |
| CHEMBL4205511 | — | — | 2 | 7.04 |
| CHEMBL4204172 | — | — | 2 | 6.85 |
| CHEMBL4203027 | — | — | 2 | 6.77 |
| CHEMBL4213094 | — | — | 1 | 6.54 |
| CHEMBL4171084 | — | — | 1 | 6.51 |
| CHEMBL4217510 | — | — | 1 | 6.33 |
| CHEMBL4215835 | — | — | 2 | 6.20 |
| CHEMBL4210991 | — | — | 1 | 6.09 |
| CHEMBL4206163 | — | — | 1 | 5.92 |
| CHEMBL4207065 | — | — | 1 | 5.72 |
| CHEMBL4204160 | — | — | 1 | 5.51 |
| CHEMBL4207266 | — | — | 1 | 5.41 |
| CHEMBL4213633 | — | — | 1 | 5.40 |
| CHEMBL4204365 | — | — | 1 | 5.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205008 | — | IC50 | = | 44.0 | nM | 7.36 |
| CHEMBL4214052 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4205511 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4204172 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4203027 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL4213094 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4171084 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL4205008 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4217510 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4215835 | — | IC50 | = | 630.0 | nM | 6.20 |
| CHEMBL4214052 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4210991 | — | IC50 | = | 820.0 | nM | 6.09 |
| CHEMBL4203027 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL4206163 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4205511 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL4207065 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4204172 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4204160 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL4215835 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4207266 | — | IC50 | = | 3900.0 | nM | 5.41 |
| CHEMBL4213633 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4204365 | — | IC50 | = | 4500.0 | nM | 5.35 |