Assay Detail
Binding
CHEMBL4199576
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to DDR1 in Sprague-Dawley rat colon tissue cell lysate using sepharose beads incubated for 45 mins by LC-MS/MS based chemoproteomics assay
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Intermediate |
Target
Epithelial discoidin domain-containing receptor 1 (CHEMBL4295859) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.50 | 7.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355009 | GSK-3179106 | 1.0 | 2 | 7.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355009 | GSK-3179106 | Kd | = | 25.12 | nM | 7.60 |
| CHEMBL3355009 | GSK-3179106 | Kd | = | 40.0 | nM | 7.40 |