Assay Detail
Binding
CHEMBL4199577
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to DDR2 in Sprague-Dawley rat colon tissue cell lysate using sepharose beads incubated for 45 mins by LC-MS/MS based chemoproteomics assay
2
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Discovery of a First-in-Class Gut-Restricted RET Kinase Inhibitor as a Clinical Candidate for the Treatment of IBS.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.18 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3355009 | GSK-3179106 | 1.0 | 2 | 7.30 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3355009 | GSK-3179106 | Kd | = | 50.12 | nM | 7.30 |
| CHEMBL3355009 | GSK-3179106 | Kd | = | 90.0 | nM | 7.05 |