Assay Detail
Functional
CHEMBL4199835
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MCF7 cells harboring PIK3CA E545K mutant after 72 hrs by MTT assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MCF7 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
Discovery of an Orally Bioavailable Dual PI3K/mTOR Inhibitor Based on Sulfonyl-Substituted Morpholinopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 6.66 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4211915 | — | — | 1 | 7.96 |
| CHEMBL4211402 | — | — | 1 | 7.82 |
| CHEMBL4208505 | — | — | 1 | 7.57 |
| CHEMBL4218707 | — | — | 1 | 7.11 |
| CHEMBL4207037 | — | — | 1 | 6.98 |
| CHEMBL4206442 | — | — | 1 | 6.95 |
| CHEMBL4214713 | — | — | 1 | 6.87 |
| CHEMBL4213772 | — | — | 1 | 6.80 |
| CHEMBL4203634 | — | — | 1 | 6.74 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 6.69 |
| CHEMBL4218171 | — | — | 1 | 6.67 |
| CHEMBL4203109 | — | — | 1 | 6.65 |
| CHEMBL4215969 | — | — | 1 | 6.55 |
| CHEMBL4204166 | — | — | 1 | 6.54 |
| CHEMBL4215235 | — | — | 1 | 6.53 |
| CHEMBL4206215 | — | — | 1 | 6.47 |
| CHEMBL4205959 | — | — | 1 | 6.39 |
| CHEMBL4210822 | — | — | 1 | 6.36 |
| CHEMBL4210301 | — | — | 1 | 6.29 |
| CHEMBL4207389 | — | — | 1 | 6.29 |
| CHEMBL4215841 | — | — | 1 | 6.24 |
| CHEMBL4205938 | — | — | 1 | 6.22 |
| CHEMBL4202499 | — | — | 1 | 6.05 |
| CHEMBL4213112 | — | — | 1 | 5.94 |
| CHEMBL4210320 | — | — | 1 | 5.82 |
| CHEMBL4216218 | — | — | 1 | - |
| CHEMBL4211255 | — | — | 1 | - |
| CHEMBL4210843 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4211915 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4211402 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4208505 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4218707 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4207037 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL4206442 | — | IC50 | = | 112.0 | nM | 6.95 |
| CHEMBL4214713 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL4213772 | — | IC50 | = | 159.0 | nM | 6.80 |
| CHEMBL4203634 | — | IC50 | = | 184.0 | nM | 6.74 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 206.0 | nM | 6.69 |
| CHEMBL4218171 | — | IC50 | = | 214.0 | nM | 6.67 |
| CHEMBL4203109 | — | IC50 | = | 224.0 | nM | 6.65 |
| CHEMBL4215969 | — | IC50 | = | 283.0 | nM | 6.55 |
| CHEMBL4204166 | — | IC50 | = | 286.0 | nM | 6.54 |
| CHEMBL4215235 | — | IC50 | = | 295.0 | nM | 6.53 |
| CHEMBL4206215 | — | IC50 | = | 340.0 | nM | 6.47 |
| CHEMBL4205959 | — | IC50 | = | 408.0 | nM | 6.39 |
| CHEMBL4210822 | — | IC50 | = | 437.0 | nM | 6.36 |
| CHEMBL4210301 | — | IC50 | = | 512.0 | nM | 6.29 |
| CHEMBL4207389 | — | IC50 | = | 513.0 | nM | 6.29 |
| CHEMBL4215841 | — | IC50 | = | 571.5 | nM | 6.24 |
| CHEMBL4205938 | — | IC50 | = | 599.0 | nM | 6.22 |
| CHEMBL4202499 | — | IC50 | = | 897.0 | nM | 6.05 |
| CHEMBL4213112 | — | IC50 | = | 1139.0 | nM | 5.94 |
| CHEMBL4210320 | — | IC50 | = | 1513.0 | nM | 5.82 |
| CHEMBL4216218 | — | IC50 | - | — | - | |
| CHEMBL4211255 | — | IC50 | - | — | - | |
| CHEMBL4210843 | — | IC50 | - | — | - |