Assay Detail
Binding
CHEMBL4199847
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Inhibition of recombinant human His-tagged p85alpha/p110alpha E542K mutant expressed in insect cells
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Discovery of an Orally Bioavailable Dual PI3K/mTOR Inhibitor Based on Sulfonyl-Substituted Morpholinopyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.75 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4211915 | — | — | 1 | 7.96 |
| CHEMBL2017974 | BUPARLISIB | 3.0 | 1 | 7.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4211915 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL2017974 | BUPARLISIB | IC50 | = | 29.0 | nM | 7.54 |