Assay Detail
Binding
CHEMBL4199878
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human N-terminal 6His/flag-tagged BMP1 (121 to 721 residues) expressed in CHO cells using ((5-FAM)-ELIDQYDVQRDDSSDGSLED-K(5,6 TAMRA)-CONH2) as substrate preincubated for 10 mins followed by substrate addition measured after 60 mins
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Reverse Hydroxamate Inhibitors of Bone Morphogenetic Protein 1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 7.16 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4204567 | — | — | 1 | 9.00 |
| CHEMBL4202714 | — | — | 1 | 9.00 |
| CHEMBL4207907 | — | — | 1 | 8.10 |
| CHEMBL4202960 | — | — | 1 | 7.70 |
| CHEMBL4202420 | — | — | 1 | 7.60 |
| CHEMBL4207308 | — | — | 1 | 7.50 |
| CHEMBL4206785 | — | — | 1 | 6.90 |
| CHEMBL4218334 | — | — | 1 | 6.80 |
| CHEMBL4218229 | — | — | 1 | 6.80 |
| CHEMBL4211285 | — | — | 1 | 5.90 |
| CHEMBL4205331 | — | — | 1 | 5.40 |
| CHEMBL4215581 | — | — | 1 | 5.20 |
| CHEMBL4211663 | — | — | 1 | - |
| CHEMBL4202848 | — | — | 1 | - |
| CHEMBL4209125 | — | — | 1 | - |
| CHEMBL4214046 | — | — | 1 | - |
| CHEMBL4205697 | — | — | 1 | - |
| CHEMBL4218415 | — | — | 1 | - |
| CHEMBL4212386 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4204567 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4202714 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4207907 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL4202960 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4202420 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4207308 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL4206785 | — | IC50 | = | 126.0 | nM | 6.90 |
| CHEMBL4218334 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4218229 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4211285 | — | IC50 | = | 1250.0 | nM | 5.90 |
| CHEMBL4205331 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4215581 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4211663 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4202848 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4209125 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4214046 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4205697 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4218415 | — | IC50 | < | 1.0 | nM | - |
| CHEMBL4212386 | — | IC50 | < | 1.0 | nM | - |