Assay Detail
Functional
CHEMBL4199967
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Antiproliferative activity against human COLO205 cells harboring BRAF V600E/D mutant measured after 4 days
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | COLO 205 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 7.44 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209570 | — | — | 1 | 8.00 |
| CHEMBL3590107 | — | — | 1 | 7.80 |
| CHEMBL4205192 | — | — | 1 | 7.66 |
| CHEMBL4213970 | MK-8353 | 1.0 | 1 | 7.64 |
| CHEMBL4218701 | — | — | 1 | 7.54 |
| CHEMBL4216900 | — | — | 1 | 7.52 |
| CHEMBL4206960 | — | — | 1 | 7.47 |
| CHEMBL4204707 | — | — | 1 | 7.39 |
| CHEMBL3645235 | — | — | 1 | 7.35 |
| CHEMBL4215228 | — | — | 1 | 7.33 |
| CHEMBL4209049 | — | — | 1 | 7.24 |
| CHEMBL4211744 | — | — | 1 | 7.12 |
| CHEMBL4216709 | — | — | 1 | 7.08 |
| CHEMBL4218370 | — | — | 1 | 7.07 |
| CHEMBL4212273 | — | — | 1 | - |
| CHEMBL4207383 | — | — | 1 | - |
| CHEMBL4203551 | — | — | 1 | - |
| CHEMBL4213444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209570 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL3590107 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4205192 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4213970 | MK-8353 | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4218701 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4216900 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4206960 | — | IC50 | = | 34.0 | nM | 7.47 |
| CHEMBL4204707 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL3645235 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL4215228 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL4209049 | — | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL4211744 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4216709 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL4218370 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL4212273 | — | IC50 | - | — | - | |
| CHEMBL4207383 | — | IC50 | > | 111.0 | nM | - |
| CHEMBL4203551 | — | IC50 | - | — | - | |
| CHEMBL4213444 | — | IC50 | > | 1000.0 | nM | - |