Assay Detail
Binding
CHEMBL4200147
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Inhibition of TNFalpha-stimulated NF-kappaB (unknown origin) expressed in HEK293 cells incubated for 30 mins followed by TNFalpha stimulation for 4 hrs by luciferase reporter gene based luminescence assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
NF-κB and Angiogenesis Inhibitors from the Aerial Parts of Chresta martii.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.53 | 6.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4205156 | — | — | 1 | 6.16 |
| CHEMBL3322516 | — | — | 1 | 6.16 |
| CHEMBL4213932 | — | — | 1 | 5.75 |
| CHEMBL4210056 | — | — | 1 | 5.66 |
| CHEMBL4218862 | — | — | 1 | 5.62 |
| CHEMBL4209530 | — | — | 1 | 5.29 |
| CHEMBL4214441 | — | — | 1 | 5.19 |
| CHEMBL4205686 | — | — | 1 | 5.11 |
| CHEMBL4217390 | — | — | 1 | 4.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4205156 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL3322516 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL4213932 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL4210056 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4218862 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4209530 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4214441 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL4205686 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL4217390 | — | IC50 | = | 13600.0 | nM | 4.87 |