Assay Detail
Binding
CHEMBL4200425
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Inhibition of human recombinant PLK1 by Z-Lyte assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK1 (CHEMBL3024) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-Guided Design and Development of Potent and Selective Dual Bromodomain 4 (BRD4)/Polo-like Kinase 1 (PLK1) Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 25 | 7.48 | 8.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4209902 | — | — | 1 | 8.96 |
| CHEMBL4207165 | — | — | 1 | 8.40 |
| CHEMBL4215729 | — | — | 1 | 8.40 |
| CHEMBL513909 | BI-2536 | 2.0 | 1 | 8.40 |
| CHEMBL4216442 | — | — | 1 | 8.08 |
| CHEMBL4202820 | — | — | 1 | 8.07 |
| CHEMBL4216875 | — | — | 1 | 8.06 |
| CHEMBL4213276 | — | — | 1 | 8.05 |
| CHEMBL4206171 | — | — | 1 | 8.00 |
| CHEMBL4210571 | — | — | 1 | 7.68 |
| CHEMBL4206052 | — | — | 1 | 7.60 |
| CHEMBL4203571 | — | — | 1 | 7.57 |
| CHEMBL3609305 | — | — | 1 | 7.49 |
| CHEMBL4214823 | — | — | 1 | 7.43 |
| CHEMBL4207437 | — | — | 1 | 7.40 |
| CHEMBL4209192 | — | — | 1 | 7.33 |
| CHEMBL3609304 | — | — | 1 | 7.27 |
| CHEMBL4215910 | — | — | 1 | 7.11 |
| CHEMBL4202678 | — | — | 1 | 7.02 |
| CHEMBL4206381 | — | — | 1 | 6.90 |
| CHEMBL4210414 | — | — | 1 | 6.80 |
| CHEMBL4212237 | — | — | 1 | 6.66 |
| CHEMBL4207347 | — | — | 1 | 6.49 |
| CHEMBL4212346 | — | — | 1 | 6.34 |
| CHEMBL4218106 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4209902 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL4207165 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4215729 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL513909 | BI-2536 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4216442 | — | IC50 | = | 8.4 | nM | 8.08 |
| CHEMBL4202820 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL4216875 | — | IC50 | = | 8.7 | nM | 8.06 |
| CHEMBL4213276 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4206171 | — | IC50 | = | 9.9 | nM | 8.00 |
| CHEMBL4210571 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4206052 | — | IC50 | = | 25.2 | nM | 7.60 |
| CHEMBL4203571 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3609305 | — | IC50 | = | 32.5 | nM | 7.49 |
| CHEMBL4214823 | — | IC50 | = | 37.2 | nM | 7.43 |
| CHEMBL4207437 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4209192 | — | IC50 | = | 47.0 | nM | 7.33 |
| CHEMBL3609304 | — | IC50 | = | 54.1 | nM | 7.27 |
| CHEMBL4215910 | — | IC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4202678 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL4206381 | — | IC50 | = | 127.0 | nM | 6.90 |
| CHEMBL4210414 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4212237 | — | IC50 | = | 218.0 | nM | 6.66 |
| CHEMBL4207347 | — | IC50 | = | 322.0 | nM | 6.49 |
| CHEMBL4212346 | — | IC50 | = | 457.0 | nM | 6.34 |
| CHEMBL4218106 | — | IC50 | = | 2620.0 | nM | 5.58 |