Assay Detail
Binding
CHEMBL4200611
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human kidney uPA using chromogenic H-D-Ile-L-Pro-L-Arg-p-nitoraniline as substrate by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.42 | 7.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217043 | — | — | 1 | 7.41 |
| CHEMBL4207715 | — | — | 1 | 6.37 |
| CHEMBL4213248 | — | — | 1 | 6.28 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 5.62 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217043 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4207715 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4213248 | — | IC50 | = | 530.0 | nM | 6.28 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 2400.0 | nM | 5.62 |