Assay Detail
Functional
CHEMBL4200626
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by CellTiter 96 Aqueous One solution cell proliferation assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-231 |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.01 | 5.50 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4207715 | — | — | 1 | 5.50 |
| CHEMBL4213248 | — | — | 1 | 4.96 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 4.56 |
| CHEMBL4217043 | — | — | 1 | - |
| CHEMBL4212068 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4207715 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4213248 | — | IC50 | = | 10900.0 | nM | 4.96 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | IC50 | = | 27300.0 | nM | 4.56 |
| CHEMBL4217043 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4212068 | — | IC50 | > | 100000.0 | nM | - |