Assay Detail
Binding
CHEMBL4200632
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mouse uPA using Z-Gly-Gly-Arg-AMC as substrate after 15 mins by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL1075311) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 4 | 5.55 | 5.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4217043 | — | — | 1 | 5.79 |
| CHEMBL4213248 | — | — | 1 | 5.74 |
| CHEMBL945 | AMILORIDE | 4.0 | 1 | 5.64 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | — | 1 | 5.03 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4217043 | — | Ki | = | 1611.0 | nM | 5.79 |
| CHEMBL4213248 | — | Ki | = | 1802.0 | nM | 5.74 |
| CHEMBL945 | AMILORIDE | Ki | = | 2313.0 | nM | 5.64 |
| CHEMBL501701 | N,N-HEXAMETHYLENEAMILORIDE | Ki | = | 9308.0 | nM | 5.03 |