Assay Detail
Binding
CHEMBL4200656
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of uPA (unknown origin)
2
Total Activities
2
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Urokinase-type plasminogen activator (CHEMBL3286) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Substituted Hexamethylene Amiloride (HMA) Derivatives as Potent and Selective Inhibitors of the Human Urokinase Plasminogen Activator for Use in Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 1 | 6.39 | 6.39 |
| IC50 | 1 | 9.21 | 9.21 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL104166 | — | — | 1 | 9.21 |
| CHEMBL4206119 | UPAMOSTAT | 2.0 | 1 | 6.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL104166 | — | IC50 | = | 0.62 | nM | 9.21 |
| CHEMBL4206119 | UPAMOSTAT | Ki | = | 410.0 | nM | 6.39 |