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Assay Detail

CHEMBL4200665

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Cytotoxicity against human PC3 cells after 72 hrs by sulforhodamine B assay
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type PC-3
Confidence 1 — Organism
Curated By Intermediate

Target

PC-3 (CHEMBL390)
Type CELL-LINE
Organism Homo sapiens

Publication

Ansamycins with Antiproliferative and Antineuroinflammatory Activity from Moss-Soil-Derived Streptomyces cacaoi subsp. asoensis H2S5.
Tang D, Liu LL, He QR, Yan W, Li D, Gao JM.
J Nat Prod (2018) 81 : 1984 -1991
PubMed 30132670 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 11 5.56 6.40

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL2017441 TRIENOMYCIN A 1 6.40
CHEMBL4208120 1 6.16
CHEMBL53463 DOXORUBICIN 4.0 1 6.10
CHEMBL4217449 1 5.58
CHEMBL4209314 1 5.57
CHEMBL4213035 1 5.38
CHEMBL4203754 1 5.36
CHEMBL4212488 1 5.35
CHEMBL4204447 1 5.35
CHEMBL4206697 1 4.99
CHEMBL4216921 1 4.92

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL2017441 TRIENOMYCIN A IC50 = 400.0 nM 6.40
CHEMBL4208120 IC50 = 700.0 nM 6.16
CHEMBL53463 DOXORUBICIN IC50 = 800.0 nM 6.10
CHEMBL4217449 IC50 = 2600.0 nM 5.58
CHEMBL4209314 IC50 = 2700.0 nM 5.57
CHEMBL4213035 IC50 = 4200.0 nM 5.38
CHEMBL4203754 IC50 = 4400.0 nM 5.36
CHEMBL4212488 IC50 = 4500.0 nM 5.35
CHEMBL4204447 IC50 = 4500.0 nM 5.35
CHEMBL4206697 IC50 = 10200.0 nM 4.99
CHEMBL4216921 IC50 = 11900.0 nM 4.92