Assay Detail
Binding
CHEMBL4200760
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG by automated patch clamp assay
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Asciminib (ABL001), an Allosteric Inhibitor of the Tyrosine Kinase Activity of BCR-ABL1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 5.38 | 5.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4106732 | — | — | 1 | 5.82 |
| CHEMBL4110570 | — | — | 1 | 5.75 |
| CHEMBL3954214 | — | — | 1 | 5.38 |
| CHEMBL4208229 | ASCIMINIB | 4.0 | 1 | 4.58 |
| CHEMBL3898258 | — | — | 1 | - |
| CHEMBL4217559 | — | — | 1 | - |
| CHEMBL4114922 | — | — | 1 | - |
| CHEMBL4213152 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4106732 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4110570 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL3954214 | — | IC50 | = | 4200.0 | nM | 5.38 |
| CHEMBL4208229 | ASCIMINIB | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL3898258 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4217559 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4114922 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4213152 | — | IC50 | > | 30000.0 | nM | - |