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Assay Detail

CHEMBL4200978

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiviral activity against Dengue virus 2 Rega infected in African green monkey Vero cells assessed as reduction in viral yield after 4 days by qRT-PCR analysis
65
Total Activities
61
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism dengue virus type 2
Cell Type Vero
Confidence 1 — Organism
Curated By Intermediate

Target

dengue virus type 2 (CHEMBL613966)
Type ORGANISM
Organism dengue virus type 2

Publication

Discovery of Indole Derivatives as Novel and Potent Dengue Virus Inhibitors.
Bardiot D, Koukni M, Smets W, Carlens G, McNaughton M, Kaptein S, Dallmeier K, Chaltin P, Neyts J, Marchand A.
J Med Chem (2018) 61 : 8390 -8401
PubMed 30149709 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 65 6.78 9.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4212403 3 9.00
CHEMBL4205902 1 8.40
CHEMBL4215935 1 8.15
CHEMBL4203720 1 7.96
CHEMBL4203293 3 7.92
CHEMBL4214447 1 7.89
CHEMBL4204690 1 7.89
CHEMBL4205665 1 7.82
CHEMBL4203207 1 7.75
CHEMBL4209676 1 7.70
CHEMBL4214655 1 7.66
CHEMBL4206605 1 7.62
CHEMBL4217606 1 7.60
CHEMBL4203212 1 7.55
CHEMBL4210976 1 7.47
CHEMBL4205724 1 7.44
CHEMBL4208464 1 7.39
CHEMBL4205131 1 7.37
CHEMBL4216359 1 7.35
CHEMBL4209010 1 7.29
CHEMBL4216831 1 7.24
CHEMBL4206685 1 7.19
CHEMBL4214021 1 7.14
CHEMBL4205295 1 7.14
CHEMBL4212873 1 7.11
CHEMBL4210136 1 7.07
CHEMBL4206172 1 7.03
CHEMBL4217780 1 7.02
CHEMBL4210261 1 7.02
CHEMBL4204641 1 6.97

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4212403 EC50 = 1.0 nM 9.00
CHEMBL4205902 EC50 = 4.0 nM 8.40
CHEMBL4215935 EC50 = 7.0 nM 8.15
CHEMBL4212403 EC50 = 7.0 nM 8.15
CHEMBL4203720 EC50 = 11.0 nM 7.96
CHEMBL4203293 EC50 = 12.0 nM 7.92
CHEMBL4214447 EC50 = 13.0 nM 7.89
CHEMBL4204690 EC50 = 13.0 nM 7.89
CHEMBL4205665 EC50 = 15.0 nM 7.82
CHEMBL4203207 EC50 = 18.0 nM 7.75
CHEMBL4209676 EC50 = 20.0 nM 7.70
CHEMBL4214655 EC50 = 22.0 nM 7.66
CHEMBL4206605 EC50 = 24.0 nM 7.62
CHEMBL4217606 EC50 = 25.0 nM 7.60
CHEMBL4203212 EC50 = 28.0 nM 7.55
CHEMBL4210976 EC50 = 34.0 nM 7.47
CHEMBL4205724 EC50 = 36.0 nM 7.44
CHEMBL4208464 EC50 = 41.0 nM 7.39
CHEMBL4205131 EC50 = 43.0 nM 7.37
CHEMBL4216359 EC50 = 45.0 nM 7.35
CHEMBL4209010 EC50 = 51.0 nM 7.29
CHEMBL4216831 EC50 = 57.0 nM 7.24
CHEMBL4203293 EC50 = 59.0 nM 7.23
CHEMBL4206685 EC50 = 65.0 nM 7.19
CHEMBL4214021 EC50 = 73.0 nM 7.14
CHEMBL4205295 EC50 = 73.0 nM 7.14
CHEMBL4212873 EC50 = 78.0 nM 7.11
CHEMBL4210136 EC50 = 85.0 nM 7.07
CHEMBL4206172 EC50 = 93.0 nM 7.03
CHEMBL4210261 EC50 = 96.0 nM 7.02
CHEMBL4217780 EC50 = 96.0 nM 7.02
CHEMBL4204641 EC50 = 106.0 nM 6.97
CHEMBL4211494 EC50 = 122.0 nM 6.91
CHEMBL4205233 EC50 = 134.0 nM 6.87
CHEMBL4209093 EC50 = 138.0 nM 6.86
CHEMBL4210531 EC50 = 138.0 nM 6.86
CHEMBL4206060 EC50 = 181.0 nM 6.74
CHEMBL4205361 EC50 = 269.0 nM 6.57
CHEMBL4218561 EC50 = 288.0 nM 6.54
CHEMBL4208984 EC50 = 288.0 nM 6.54
CHEMBL4216943 EC50 = 297.0 nM 6.53
CHEMBL4212403 EC50 = 348.0 nM 6.46
CHEMBL4218425 EC50 = 391.0 nM 6.41
CHEMBL4218426 EC50 = 406.0 nM 6.39
CHEMBL4203293 EC50 = 456.0 nM 6.34
CHEMBL4214143 EC50 = 484.0 nM 6.32
CHEMBL4215399 EC50 = 590.0 nM 6.23
CHEMBL4213495 EC50 = 837.0 nM 6.08
CHEMBL4217011 EC50 = 926.0 nM 6.03
CHEMBL4208082 EC50 = 1200.0 nM 5.92