Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4201221

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Rhinovirus B14 capsid infected in human HeLa Rh cells assessed as reduction in virus-induced cytopathic effect after 3 days by MTS assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism rhinovirus B14
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

VP1 capsid protein (CHEMBL3833484)
Type SINGLE PROTEIN
Organism Human rhinovirus sp.

Publication

Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication.
Da Costa L, Scheers E, Coluccia A, Casulli A, Roche M, Di Giorgio C, Neyts J, Terme T, Cirilli R, La Regina G, Silvestri R, Mirabelli C, Vanelle P.
J Med Chem (2018) 61 : 8402 -8416
PubMed 30153009 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 21 6.37 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL29609 PLECONARIL 2.0 1 7.52
CHEMBL4208180 1 7.46
CHEMBL4208286 1 7.22
CHEMBL4209270 1 6.89
CHEMBL4215079 1 6.75
CHEMBL4214859 1 6.70
CHEMBL4214159 1 6.60
CHEMBL4211585 1 6.60
CHEMBL4206699 1 6.40
CHEMBL4202881 1 6.40
CHEMBL4206751 1 6.30
CHEMBL4213133 1 6.23
CHEMBL4213669 1 6.00
CHEMBL4208731 1 5.92
CHEMBL4213556 1 5.89
CHEMBL4203308 1 5.60
CHEMBL4206357 1 5.19
CHEMBL4218496 1 5.06
CHEMBL4218642 1 -
CHEMBL4210150 1 -
CHEMBL4213214 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL29609 PLECONARIL EC50 = 30.0 nM 7.52
CHEMBL4208180 EC50 = 35.0 nM 7.46
CHEMBL4208286 EC50 = 60.0 nM 7.22
CHEMBL4209270 EC50 = 128.0 nM 6.89
CHEMBL4215079 EC50 = 180.0 nM 6.75
CHEMBL4214859 EC50 = 200.0 nM 6.70
CHEMBL4214159 EC50 = 250.0 nM 6.60
CHEMBL4211585 EC50 = 250.0 nM 6.60
CHEMBL4206699 EC50 = 400.0 nM 6.40
CHEMBL4202881 EC50 = 400.0 nM 6.40
CHEMBL4206751 EC50 = 500.0 nM 6.30
CHEMBL4213133 EC50 = 590.0 nM 6.23
CHEMBL4213669 EC50 = 1000.0 nM 6.00
CHEMBL4208731 EC50 = 1200.0 nM 5.92
CHEMBL4213556 EC50 = 1300.0 nM 5.89
CHEMBL4203308 EC50 = 2500.0 nM 5.60
CHEMBL4206357 EC50 = 6400.0 nM 5.19
CHEMBL4218496 EC50 = 8700.0 nM 5.06
CHEMBL4218642 EC50 > 247000.0 nM -
CHEMBL4210150 EC50 > 247000.0 nM -
CHEMBL4213214 EC50 > 128000.0 nM -