Assay Detail
Binding
CHEMBL4201228
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Inhibition of Rhinovirus A89 capsid infected in human HeLa Rh cells assessed as reduction in virus-induced cytopathic effect after 3 days by MTS assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | rhinovirus A89 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Structure-Based Drug Design of Potent Pyrazole Derivatives against Rhinovirus Replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.64 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29609 | PLECONARIL | 2.0 | 1 | 8.40 |
| CHEMBL4203308 | — | — | 1 | 6.72 |
| CHEMBL4213214 | — | — | 1 | 5.82 |
| CHEMBL4208180 | — | — | 1 | 5.62 |
| CHEMBL4208286 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29609 | PLECONARIL | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4203308 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4213214 | — | EC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL4208180 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4208286 | — | EC50 | > | 128000.0 | nM | - |